Hi Geertjan,
Typically you should be fine.
https://help.maxon.net/us/index.html#PREFSMEMORY-PREF_MEMORY_MAIN_GROUP
As usual, I like to have a practical base to answer, and not just parroting what I read.
Of course, I used the last hours to check out different scenarios. I even re-animated a ten-year-old computer with just 8GB, hence the long time to evaluate this. All machines I have checked worked just fine (30Kx30K, each 16bit/channel, or 32b/c., I consider for the production pipeline 8bit/channel as unusable, hence why I excluded it here.)
The used memory on my newest machine was bigger than the final file, in other words, the file size is not the way to determine what an ideal machine would need, there are many factors to consider.
In any case, the switch from RAM to any none SSD drive, as you know, will slow down dramatically the rendering.
All the best
I used the Mac> Activity Monitor to gain my data.