Hi bencinema,
I can read and use anything in default even if I have 5K enabled (P3, 27”). Typically I stay in 2.5K as I do screen recordings.
Make sure that the icons (if you have them in the interface enabled), are set to RMC: Icon Size> Large, otherwise, they are really tiny. This needs to be done for each group of Icons, sorry, no general setting. Save the layout.
The preferences have no further options, other than the text size (Interface>GUI Font> 3rd pull don menu, default is 11)
I assume that you don’t ask how to adjust the interface to get the size of the screen. Sorry to even mention it, but your question leaves a lot for interpretation.
The Icons were improved for more current resolutions. Anything else, I fear I can’t tell more what you need from your short question, needs to be solved by the support.
https://www.maxon.net/en/support-center
All the best
For anyone reading along and who is not familiar with abbreviation RMC: right mouse click