Hi markfug,
First: Have you tried to set new short cuts?
Sorry to hear about your trouble with this. Before I send you to the roundtrip, as I’m not supposed to do technical stuff here, let me make sure we have excluded a few things. (Yes, I got that you get no further response, and I really don’t know what to make of it, that is not the way I know it. Anyway not the place to discuss here, as I would need to hear both sides, and that goes beyond the scope of the forum here. I hope that makes sense).
I had a similar problem with Photoshop, my most use short cut “X” wasn’t available anymore, took me weeks to it figure out, yes tons of online forum advice (nothing helped!), so I feel you pain. Turned out, it happens only when Chrome was running as well. Since you had trouble in earlier post with Safari, I mention Chrom, as Chrome is normally working with this forum. I have had more trouble with Ps when Chrome is running, but all comes after a while back, restart helps. Sounds familiar?
If you have a second Mac, do you experience the same?
I guess you are on the latest build os and app wise.
Besides that, the first rule of finding other problems, pull all cables, besides power of course. A broken USB cable or anything with BlueTooth might be the problem. Besides that, someone told me that the cell phone was the problem in his case.
In other words, excluding as problem solving strategy. Keyboards and mouse/tablet stuff, especially Wacom has driven me nuts at one point, New drivers have helped sometimes.
Another option, these weird sleep mode hard drives. While the Mac sends the drive to sleep, some drives have their own sleep mode, and that creates a wake up problem. If any app needs access to the drive for that short cut, you are left alone. For my new 8TB WD drives I leave the Utilities open, which helps to keep them active. Also here, the WD support is silence.
PRAM and other resets should be done if things go south; Often kind of completely unrelated, I know, but if there is a chain reaction…
That’s all I can share.
Fingers crossed.
My best wishes.