Hi Trick65,
Do you expect on each layer a completely different rendering of the scene with perhaps even different textures and light, then the answer is no, not possible.
To do this would require to use Takes and render our different version of the scene, then use a Ps action script to combine all of these: Load image into a stackā¦
If you like to have different passes of the scene, as in Depth, RGBA, UV, Motion, etc., then that is a given with Multi-Pass.
I’m not sure if your question could be understood as in not having a multi-layered file, and if each image information placed in a single psd file could be saved directly as one image (layer) file.
If this isn’t answering your question, please elaborate and detail your question perhaps. I’m happy to look into it then.
All the best